Spontaneous regression of low-grade cervical intraepithelial lesions is positively improved by topical bovine colostrum preparations (GINEDIE®). A multicentre, observational, italian pilot study

C Stefani 1, C A Liverani, V Bianco, C Penna, T Guarnieri, C Comparetto, E Monti, I Valente, A L Pieralli, C Fiaschi, M Origoni

Eur Rev Med Pharmacol Sci. 2014;18(5):728-33.

https://pubmed.ncbi.nlm.nih.gov/24668716/

Abstract

Objectives: Human papillomavirus (HPV) is the causal agent of cervical cancer. The great majority of abnormal Pap test results – almost 90% – is referrable to either atypical squamous intraepithelial lesion or CIN1. For these lesions, worldwide agreement exists concerning the high rate – ranging from 40% to 70% – of spontaneous regression over a period of 1-5 years. Host’s immune response is a key point influencing the natural history of these conditions. Bovine colostrum is a natural agent positively promoting several immune activities against bacterial and viral agents. The aim of this report was to evaluate the potential positive effect of bovine colostrum-containing vaginal tablets administered to CIN1 diagnosed patients in a prospective trial in regards to spontaneous regression rate.

Results: Overall regression rate to a negative histology at the end of the 6 month follow up was 75.5%.

Conclusions: Regression to normal histology was observed in a very high rate of cases in a very short period compared to the natural history of these lesions. CIN1 patients could benefit from bovine colostrum topical administration in terms of significantly shortening the regression time.